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宋健平

时间:2018-09-14 13:55  作者: 文章来源: 点击:[]

    宋健平教授参加WHO专家会照片-1

宋健平,热带医学研究所所长,教授

邮箱:songjp@gzucm.edu.cn

导师类别:博士生导师

研究方向:青蒿素防治疟疾、全球疟疾防治策略研究和治疗糖尿病中药开发

个人简介:

宋健平,生于1965年,江西会昌人。现任广州中医药大学研究员,珠江学者,博士生导师,热带医学研究所所长、青蒿研究中心主任,广东省珠江学者特聘教授,兼任世界卫生组织(WHO)临时疟疾顾问,全国消除疟疾专家指导组委员、国家中医药管理局对外交流合作专家咨询委员、广东省中西医结合学会感染病专业委员会副主任委员等职务。

宋健平研究员长期致力于中医药防治重大疾病尤其是热带病临床和科研工作,主要研究领域为青蒿素防治疟疾、全球疟疾防治策略研究和治疗糖尿病中药开发,是我国青蒿素复方临床研究和推广应用团队主要成员,在《自然·遗传》、《柳叶刀·传染病》、《临床传染病》等国内外知名杂志发表或合作发表学术论文50多篇。先后主持和参加美国国立卫生研究院(NIH)合作课题、国家自然科学基金、科技部国际科技合作项目等国家、省部、市级课题30余项,研究成果曾获国家和省部科技奖。

宋健平研究员长期坚持在亚非疟疾流行地区从事疟疾防治工作,承担国家援外抗疟任务,培养了一批具有国际视野的科研人才。他参与组织的科摩罗(80万人口)复方青蒿素(Artequick®)快速控制和清除疟疾项目,利用中国原创的青蒿素复方,通过主动的群体药物干预,有效地遏制了疟疾流行,短时间内实现了从高度疟疾流行区向低疟区的转变,实现了疟疾零死亡,该项目成果受到WHO和国际学术界的关注。他参加编写的WHO《恶性疟全民服药操作手册》,将广东青蒿抗疟团队在科摩罗取得的经验写入指南。

主持的代表性项目:

援科摩罗抗疟中心技术援助项目,2018-2020,商务部援外项目

援圣多美和普林西比疟疾防治顾问技术援助项目,2017-2020,商务部援外项目

中国广东-巴布亚新几内亚疟疾防治中心建设项目,2018,广东省人民政府外事办公室

青蒿素联合凉血散血药对脑型疟营血分证脑部血管周细胞的影响,2019-2022,国家自然科学基金项目

中非疟疾防治中心,2018,国家中医药管理局中医药国际合作专项

中国-多哥中医药中心,2017/1/1,国家中医药管理局中医药国际合作专项

中国-马拉维中医药中心,2016/1/1,国家中医药管理局中医药国际合作专项

中国-马拉维青蒿素抗疟中心,2015/1/1,国家中医药管理局中医药国际合作专项

科摩罗昂儒昂岛复方青蒿素清除疟疾示范项目,2013/10/1,国家中医药管理局国际合作专项

猴脑型疟证治规律的研究,2013/1/1,国家自然科学基金项目

中医药防治重大疑难疾病临床服务能力建设-疟疾,2016/1/1,广东省中医药局

中医药文化科普宣传和服务贸易试点项目,2016/1/1,广东省中医药局

青蒿素类抗疟药的安全性再研究,2015/1/1,广东省教育厅,高层次人才项目-珠江学者特聘教授

中国-科摩罗疟疾防治中心后期建设项目,2015/1/1,广东省科技厅,国际合作项目

研究成果(代表性论文):

(1)     Changsheng Deng, Bo Huang, Qi Wang, Wanting Wu,Shaoqin Zheng,Hongying Zhang,Di Li,Danghong Feng, Guoming Li, Linlu Xue,Tao Yang, Fei Tuo, Fouad Mohadji, Xin-zhuan Su, Qin Xu, Zhibing Wu, Li Lin, Jiuyao Zhou, Hong Yan, Affane Bacar, Kamal Said Abdallah,Rachadi A. Kéké, Ahamada Msa Mliva, Moussa Mohamed, Xinhua Wang, Shiguang Huang, Fatihou Oithik, Xiao-bo Li, Fangli Lu, Michael P. Fay, Xiao-hong Liu, Thomas E. Wellems, and Jianping Song*. Large-scale Artemisinin–Piperaquine Mass Drug Administration With or Without Primaquine Dramatically Reduces Malaria in a Highly Endemic Region of Africa, Clinical Infectious Diseases, 2018-04-24, DOI: 10.1093/cid/ciy364.

(2) . Bo Huang, Fei Tuo, Yuan Liang, Wanting Wu, Guangchao Wu, Shiguang Huang, Qirun Zhong,Xin‑zhuan Su, Hongying Zhang, Mingqiang Li, Affane Bacar, Kamal Said Abdallah, Ahamada M. S. A. Mliva,Qi Wang, Zhaoli Yang, Shaoqin Zheng, Qin Xu, Jianping Song* and Changsheng Deng*. Temporal changes in genetic diversity of msp‑1, msp‑2, and msp‑3 in Plasmodium falciparum isolates from Grande Comore Islandafter introduction of ACT, Malaria Journal, 2018, 17:83, https://doi.org/10.1186/s12936-018-2227-3.

(3). Bo Huang, Qi Wang, Changsheng Deng, Jianhua Wang, Tao Yang, Shiguang Huang, Xin‑zhuan Su, Yajun Liu, Longhua Pan, Guoming Li, Di Li, Hongying Zhang, Afane Bacar, Kamal Said Abdallah, Rachad Attoumane, Ahamada M. S. A. Mliva, Shaoqin Zheng, Qin Xu, Fangli Lu, Yezhi Guan* and Jianping Song*. Prevalence of crt and mdr-1 mutations in Plasmodium falciparum isolates from Grande Comore island after withdrawal of chloroquine. Malaria Journal, 2016, 15:414.

(4). Bo Huang, Changsheng Deng, Tao Yang, Linlu Xue, Qi Wang, Shiguang Huang, Xin-zhuan Su, Yajun Liu, Shaoqin Zheng, Yezhi Guan , Qin Xu , Jiuyao Zhou, Jie Yuan , Afane Bacar, Kamal Said Abdallah, Rachad Attoumane, Ahamada M. S. A.Mliva, Yanchun Zhong, Fangli Lu and Jianping Song*. Polymorphisms of the artemisinin resistant marker (K13) in Plasmodium falciparum parasite populations of Grande ComoreIsland 10 years after artemisinin combination therapy. Parasites & Vectors, 8:634.

(5). Jianping Song, Duong Socheat, Bo Tan, Prak Dara, Changsheng Deng, Sreng Sokunthea, Suon Seila, Fengzhen Ou, Huaxiang Jian, Guoqiao Li*. Rapid and effective malaria control in Cambodia through mass administration of artemisinin-piperaquine. Malaria Journal, 2010, 9:57.

(6). Jianping Song*, Duong Socheat, Bo Tan, Suon Seila, Ying Xu, Fengzhen Ou, Sreng Sokunthea, Leap Sophorn, Chongjun Zhou, Changsheng Deng, Qi Wang and Guoqiao Li. Randomized trials of artemisinin-piperaquine, dihydroartemisinin-piperaquine phosphate and artemether-lumefantrine for the treatment of multi-drug resistant falciparum malaria in Cambodia-Thailand border area. Malaria Journal, 2011, 10:231.

(7). Richard J. Maude*, Duong Socheat, Chea Nguon, Preap Saroth, Prak Dara, Guoqiao Li, Jianping Song, Shunmay Yeung, Arjen M. Dondorp, Nicholas P. Day, Nicholas J. White, Lisa J. White. Optimising Strategies for Plasmodium falciparum Malaria Elimination in Cambodia: Primaquine, Mass Drug Administration and Artemisinin Resistance. PLoS ONE 7(5): e37166. doi:10.1371/journal.pone.0037166

(8). Jianbing Mu, Rachel A Myers, Hongying Jiang, Shengfa Liu, Stacy Ricklefs, Michael Waisberg, Kesinee Chotivanich, Polrat Wilairatana, Srivicha Krudsood, Nicholas J White, Rachanee Udomsangpetch, Liwang Cui, May Ho, Fengzhen Ou, Haibo Li, Jianping Song, Guoqiao Li, Xinhua Wang, Suon Seila, Sreng Sokunthea, Duong Socheat, Daniel E Sturdevant, Stephen F Porcella, Rick M Fairhurst, Thomas E Wellems, Philip Awadalla & Xin-zhuan Su. Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs. Nature Genetics, 2010, doi:10.1038/ng.528

(9). Chanaki Amaratunga, Sokunthea Sreng, Seila Suon, Erika S Phelps, Kasia Stepniewska, Pharath Lim, Chongjun Zhou, Sivanna Mao, Jennifer M Anderson, Niklas Lindegardh*, Hongying Jiang, Jianping Song, Xin-zhuan Su, Nicholas J White, Arjen M Dondorp, Tim J C Anderson, Michael P Fay, Jianbing Mu, Socheat Duong, Rick M Fairhurst. Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study. Lancet, Published online August 30, 2012 http://dx.doi.org/10.1016/S1473-3099 (12)70181-0.

(10). Trieu Nguyen Trung, TAN Bo, Dang Van Phuc, and SONG Jian-ping*. A randomized, controlled trial of artemisinin-piperaquine vs dihydroartemisinin-piperaquine phosphate in treatment of falciparum malaria. Chin J Integr Med, 2009, 15(3):89-192.

(11). SONG Jian-ping, Duong Socheat, and Suou Seila. A comparative study of dihydroartemisinin compounds in the treatment of uncomplicated falciparum malaria in Kampong of Cambodia. Chin J Integr Med, 2003, 9(1):31-34.

(12). Changsheng Deng, Qi Wang, Shaoqin Zheng, Chongjun Zhou, Yan Gao, Jiawen Guo, Ahamada MSA Mliva, Fatihou Oithik, Anfane Bacar, Rachad Attoumane and Jianping Song*. Mass Drug Administration of Artemisinin-piperaquine on High Malaria Epidemic Area, Tropical Medicine and Health, Vol. 42 No.2 Supplement, 2014, 33-41.

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