徐勤，广州中医药大学，热带医学研究所，教授
邮箱：xuqin@gzucm.edu.cn
导师类别：博士生导师
研究方向：中药毒理学研究，中药抗肿瘤研究
个人简述
徐勤 男。籍贯: 江苏江都市（现扬州市江都区）。1963年1月出生。热带医学研究所副所长,中药学专业教授。毕业于中山医学大学（现中山大学医学院）肿瘤病理专业(硕士)。兼任中国毒理学会药物毒理及安全评价专业委员会委员、中国药学会毒性病理专业委员会委员、中国药理学会安全药理专业委员会委员、广东省中药药理专业委员会常委、广东省药物毒理专业委员会常委、广东省医疗协会病理医生协会委员，广州中医药大学学报编委、安徽医药编委，国家食品药品管理局新药审评专家、广东省新药审评专家，广东省“杨帆计划”入库专家、广东省科技计划审评专家。主持及承担各类科研项目40余项，在中药、小分子化学药及生物制品的临床前研究方面具有丰富的经验，参与各类新药研发100余项，包括多个销售额10亿以上的中药大品种。主持的各类横向研究课题经费合计2500余万元。主编教材1本、参编教材2本（教育部规划教材1本），参编专著1本（中药毒性与临床前评价）；讲授课程2门。获国家中医药管理局学术专著一等奖1项、广东省中医药科技进步二等奖1项。在ACS Appl Mater Inter 等SCI期刊及国内杂志发表学术论文50余篇。主要研究方向为：（1）中药毒理学研究 （2）中药抗肿瘤研究。目前为岭南药物毒理学研究团队负责人。已培养毕业硕士生14人、在读研究生10人，其中3名研究生获国家奖学金，另有3人获广州中医药大学优秀毕业生
教育经历:
1. 1992/07-1995/07，中山医科大学，肿瘤病理专业，硕士
2. 1980/08-1985/07，皖南医学院，医疗系临床医疗专业，学士
工作经历:
1. 2010/11-至今，广州中医药大学，热带医学研究所，教授
2. 2003/07-2010/10，广州中医药大学，基础医学院，副教授，教授
3. 2000/11-2002/01，广州中医药大学，国家新药安评重点实验室，副教授
4. 1995/07-2000/11，广州中医药大学，病理教研室病理教学，讲师
5. 1985/07-1992/07，皖南医学院，病理教研室，助教
主持或参加科研项目:
1. 广东省教育厅“创新强校工程”专项资金项目，2016KYTD06，岭南药物毒理学研究团队—基于传统毒理学-计算科学的中药心脏毒评价及预测，2016/06-2017/06，90万元，已结题，主持
2. 广州市科技计划项目，20160505020，中药安全性评价第三方服务机构，2016/05-2017/04，50万元，已结题，主持
3. 广东省科技计划项目，2015A040404042，新药临床前安全评价服务平台（GLP）建设，2015/12-2018/12，50万，在研，主持
4. 广东省“扬帆计划”引进创新创业团队项目，2014YT02S008，基于优质青蒿综合利用的南药开发创新研究，2015/04-2020/03，300万，在研，参加（排名第2，核心成员）
5. 国家自然基金面上项目，81273843，猴脑型疟证治规律的研究，2013/01-2016/12，70万，已结题，参与
6. 广东省产业技术与研究开发入库项目，2012B010300003，内分泌系统安全评价关键技术研究，2012/08-2014/08，18万元，已结题，主持
发表论文：
(1) Feng Zeng#, Yahong Shi#, Chunni Wu, Jianming Liang, Qixin Zhong, Karen Briley, Bin Xu, Yongzhuo Huang, Manmei Long, Cong Wang, Jian Chen, Yonghua Tang, Xinying Li, Mengda Jiang, Luting Wang, Qin Xu, Liu Yang, Peng Chen, Shengzhong Duan, Jingyuan Xie*, Cong Li*, Yingwei Wu*. A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease. J. Nanobiotechnol., 2022, 20, 107.
(2) Canhao Wu†, Qin Xu†, Huiyuan Wang, Bin Tu, Jiaxin Zeng, Pengfei Zhao, Mingjie Shi, Hong Qiu, Yongzhuo Huang* Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles. Acta Pharmaceutica Sinica B.2022, 12(3):1523-1533.
(3) Aihua Wu, Yingzhi Chen, Hairui Wang, Ya Chang, Meng Zhang, Pengfei Zhao, Yisi Tang, Qin Xu*, Zhuangzhi Zhu, Yang Cao, Yongzhuo Huang*. Genetically-engineered “all-in-one” vaccine platform for cancer immunotherapy, Acta Pharmaceutica Sinica B. 2021, 11(11): 3622-3635.
(4) Yuefei Fang#, Yang He #, Canhao Wu, Meng Zhang, Zeyun Gu, Jiaxin Zhang, Ergang Liu, Qin Xu*, Akmal M. Asrorov, Yongzhuo Huang*, Magnetism-mediated targeting hyperthermia immunotherapy in “cold” tumor with CSF1R inhibitor, Theranostics,2021; 11(14): 6860-6872.
(5) Xiaobo Li , Zhouqing He , Li Ru , Yueming Yuan, Zheng Yuan, Pengfei Chen, Zhiyong Xu , Qi Wang , Jianping Song * and Qin Xu* Effificacy and Safety of Qinghao Biejia Decoction in the Treatment of Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology, 2021,:2028
(6) Lingling Xiang, Haiting Wu, Yushi Liang, Huiying Deng, Yiting He, Qin Xu*, Jing Zhang*. Ag(I)-Catalyzed rapid access to 2-amino-4-methylenethiazolines with potential applications in bioconjugation chemistry. Organic & Biomolecular Chemistry. 2021, 19(18): 4060-4066.
(7) Zening Zheng, Jiaxin Zhang, Jizong Jiang, Yang He, Wenyuan Zhang, Xiaopeng Mo, Xuejia Kang, Qin Xu*, Bing Wang, Yongzhuo Huang*. Remodeling tumor immune microenvironment (TIME) for glioma therapy using multi-targeting liposomal codelivery. Journal for ImmunoTherapy of Cancer 2020; 8:e000207.
(8) T. Deng, X. Wang, S. Wu, S. Hu, W. Liu, T. Chen, Z. Yu, Q. Xu* and F. Liu*. A new FRET probe for ratiometric fluorescence revealing mitochondria-localized drug activation and imaging endogenous hydroxyl radicals in zebrafish. Chem. Commun., 2020, 56, 4432-4435.
(9) Xuejia Kang#, Zening Zheng#, Zehua Liu, Huiyuan Wang, Yuge Zhao, Wenyuan Zhang, Mingjie Shi, Yang He, Yang Cao, Qin Xu*, Chengyuan Peng, Yongzhuo Huang*, Liposomal codelivery of doxorubicin and andrographolide inhibits breast cancer growth and metastasis, Mol Pharm, 2018, DOI: 10.1021/acs.molpharmaceut.7b01164
(10) Bo Huang, FeiTuo, Yuan Liang, Wanting Wu, Guangchao Wu, Shiguang Huang, QirunZhong, Xin‑zhuan Su, Hongying Zhang, Mingqiang Li, AffaneBacar, Kamal Said Abdallah, Ahamada M. S. A. Mliva, Qi Wang, Zhaoli Yang, Shaoqin Zheng, Qin Xu, Jianping Song*, Changsheng Deng*, Temporal changes in genetic diversity of msp-1, msp-2, and msp-3 in Plasmodium falciparum isolates from Grande Comore Island after introduction of ACT, Malar J, 2018, 17: 83
(11) Yisi Tang#, Jianming Liang#, Aihua Wu, Yingzhi Chen, Pengfei Zhao, Tingting Lin, Meng Zhang, Qin Xu*, Jianxin Wang*, Yongzhuo Huang*, Co-delivery of trichosanthin and albendazole by nano-self-assembly for overcoming tumor multidrug-resistance and metastasis, ACS Appl Mater Interfaces, 2017, 9(32): 26648–26664
(12) Qi Wang, Shui-Qing Huang, Chang-Qing Li, Qin Xu*, Qing-Ping Zeng*, Akkermansiamuciniphila may determine chondroitin sulfate ameliorating or aggravating osteoarthritis, Front Microbiol, 2017, 8: 1955
(13) Xue-jia Kang, Hui-yuan Wang, Hui-ge Peng, Bin-fan Chen, Wen-yuan Zhang, Ai-hua Wu, Qin Xu*, Yong-zhuo Huang*, Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy, ActaPharmacol Sin, 2017, 38(6): 885-896
(14) Yingzhi Chen, Meng Zhang, HongyueJin, Yisi Tang, Aihua Wu, Qin Xu, Yongzhuo Huang*, Prodrug-like, PEGylated protein toxin trichosanthin for reversal of chemoresistance,Mol Pharm, 2017, 14(5): 1429-1438
(15) Yingzhi Chen, Meng Zhang, HongyueJin, Yisi Tang, Huiyuan Wang, Qin Xu, Yaping Li, Feng Li, Yongzhuo Huang*, Intein-mediated site-specific synthesis of tumor-targeting protein delivery system: Turning PEG dilemma into prodrug-like feature, Biomaterials, 2017, 116: 57-68
(16) Yanna Cui#, Meng Zhang#, Feng Zeng, HongyueJin, Qin Xu, Yongzhuo Huang*, Dual-targeting magnetic PLGA nanoparticles for codelivery of paclitaxel and curcumin for brain tumor therapy, ACS Appl Mater Interfaces, 2016, 8(47):32159-32169
(17) Bo Huang#, Qi Wang#,Changsheng Deng, Jianhua Wang, Tao Yang, Shiguang Huang, Xin‑zhuan Su, Yajun Liu, Longhua Pan, Guoming Li, Di Li, Hongying Zhang, AfaneBacar, Kamal Said Abdallah, RachadAttoumane, Ahamada M. S. A. Mliva, Shaoqin Zheng, Qin Xu, Fangli Lu, Yezhi Guan, Jianping Song*, Prevalence of crt and mdr-1 mutations in Plasmodium falciparum isolates from Grande Comore island after withdrawal of chloroquine, Malar J, 2016, 15(1):414
(18) Bo Huang#, Changsheng Deng#, Tao Yang, LinluXue,Qi Wang, Shiguang Huang, Xin-zhuan Su, Yajun Liu, Shaoqin Zheng, YezhiGuan, QinXu, Jiuyao Zhou, JieYuan, AfaneBacar, Kamal Said Abdallah, RachadAttoumane, Ahamada M. S. A. Mliva, YanchunZhong, Fangli Lu, Jianping Song*, Polymorphisms of the artemisinin resistant marker (K13) in Plasmodium falciparum parasite populations of Grande Comore Island 10 years after artemisinin combination therapy, Parasit Vectors, 2015, 8: 634
