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张静

时间:2018-09-08 15:56  作者: 文章来源: 点击:[]


     

张静 校聘研究员

邮箱:jingzhang@gzucm.edu.cn

所属学院(所):热带医学研究所

导师类别:硕士生导师

科研方向:以表观遗传学为中心的化学生物学、药物化学和新型有机方法学研究

 

        个人简述

张静, 杏林青年学者(校聘研究员)。2011年博士毕业于中国科学院上海药物研究所,随后先后在美国麻省大学医学院和佐治亚大学从事博士后研究。发表SCI论文16篇,申报中国发明专利2项、美国发明专利1项。博士期间获得第二届世界组合科学大学最佳墙报奖,博士后期间获得美国心脏协会博士后基金资助。20183月加入广州中医药大学热带医学研究所。其课题组致力于围绕表观遗传学的化学生物学、药物研发和新型有机方法学的研究,以及它们在防治传染性疾病中的应用。

教育背景

2006.9 - 2011.7  药物化学专业,博士学位,中国科学院上海药物研究所

工作经历

2011.10 - 2014.3 博士后,骨科和物理康复科,麻省大学医学院(Department of Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School

2014.3 – 2018.01博士后,佐治亚大学药学院(College of Pharmacy, University of Georgia

主要论文

1.     Melody D. Fulton*, Jing Zhang*, Maomao He, Meng-Chiao Ho, Yujun George Zheng. Intricate Effects of α-Amino and Lysine Modifications on Arginine Methylation of the N-Terminal Tail of Histone H4. Biochemistry. 2017, 56, 3539-3548. (* co-first author)

2.     Jing Zhang*, Kun Qian*, Chunli Yan, Maomao He, Brenson A. Jassim, Ivaylo Ivanov, Yujun George Zheng. Discovery of decamidine as a new and potent PRMT1 inhibitor. Med. Chem. Commun., 2017, 8, 440-444. (* co-first author)

3.     Jing Zhang, George Yujun Zheng. SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases. ACS Chem Biol. 2016, 11, 583-97.

4.     Ruo-Jing Li, Jing Xu, Chenglai Fu, Jing Zhang, Yujun George Zheng, HaoJia, Jun O Liu. Regulation of mTORC1 by lysosomal calcium and calmodulin. eLife. 2016, 5, e19360.

5.     Yepeng Luan, Levi L. Blazer, Hao Hu, TaranehHajian, Jing Zhang, Hong Wu, Scott Houliston, Chery H. Arrowsmith, MasoudVedadi, Yujun George Zheng. Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1. Org. Biomol. Chem. 2016, 14, 631-638.

6.     Jing Zhang,Jiye Huang, Zilan Song, Lin Guo, WenxianCai, Yun Wang, Xuechu Zhen, Ao Zhang. Structural manipulation on the catecholic fragment of dopamine D1 receptor agonist 1-phenyl-N-methyl-benzazepines. Eur. J. Med. Chem. 2014, 85, 16-26.

7.     Jing Zhang,Jie Song. Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. ActaBiomaterialia. 2014, 10, 3079-3090.

8.     Zhiqing Liu, Jing Ai, Xia Peng, Zilan Song, Kui Wu, Jing Zhang, Qizheng Yao, Yi Chen, Yinchun Ji, Yanhong Yang, Mei-Yu Geng, Ao Zhang. Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities. ACS Med Chem Lett. 2014, 5, 304-308.

9.     Jing Zhang,Kui Wu, Meining Wang, Jianqin Jiang and Ao Zhang. FeCl3·6H2O-Promoted Skeleton-Rearrangement of 1-Substituted-3-benzazepines: Substrate Extension and Product Utilization. Tetrahedron. 2011, 67, 842-848.

10.   Zhili Liu, Hai Zhang, Na Ye, Jing Zhang,QianQian Wu, Peihua Sun, Linyong Li, Xuechu Zhen, and Ao Zhang. Synthesis of Dihydrofuroaporphine Derivatives: Identification of a Potent and Selective Serotonin 5-HT1A Receptor Agonist. J. Med. Chem. 2010, 53, 1319-1328.

11.   Jing Zhang, Bing Xiong, Xuechu Zhen and Ao Zhang. Dopamine D1 receptor ligands: where are we now and where are we going. Med. Res. Rev. 2009, 29, 272-294.

12.   Jing Zhang, Hai Zhang, WenxianCai, Leiping Yu, Xuechu Zhen and Ao Zhang. 'Click' D1 receptor agonists with a 5-HT1A receptor pharmacophore producing D2 receptor activity. Bioorg. Med. Chem. 2009, 17, 4873-4880.

13.   Jing Zhang,Ao Zhang. Unprecedented FeCl3 6H2O-promoted skeleton rearrangement of 1-aryl-2,3,4,5-tetrahydro-1H-3-benzazepines: a new strategy for the synthesis of C1 quaternary tetrahydroisoquinolines. Chem. Eur. J. 2009, 15, 11119-11122.

14.   Zhili Liu, Jing Zhang and Ao Zhang. Design of multivalent ligand targeting G-protein-coupled receptors. Curr. Pharm. Des. 2009, 15, 682-718.

15.   Xueqing Chen, Jing Zhang, John L Neumeyer, GuozhangJin, Guoyuan Hu, Ao Zhang and Xuechu Zhen. Arylbenzazepines are potent modulators for the delayed rectifier K+ channel: a potential mechanism for their neuroprotective effects. Plos One 2009, 4, e5811.

16.   Jing Zhang,Xuetao Chen, Leiping Yu, Xuechu Zhen and Ao Zhang. Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D1 receptor activities. Bioorg. Med. Chem. 2008, 16, 9425-9431.

科研项目

1. 高水平大学建设杏林人才科研配套经费,2018/03-2021/03.

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