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张静

时间:2018-09-08 15:56  作者: 文章来源: 点击:[]

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张静 副研究员

邮箱:jingzhang@gzucm.edu.cn

导师类别:硕士生导师

科研方向:化学生物学,药物化学,有机方法学

招收学科类别:中药学,药物化学

个人简述

张静,杏林青年学者,副研究员。2011年博士毕业于中国科学院上海药物研究所,随后先后在美国麻省大学医学院和佐治亚大学从事博士后研究。博士期间获得第二届世界组合科学大学“最佳墙报奖”,博士后期间获得美国心脏协会博士后基金资助。2018年3月加入广州中医药大学热带医学研究所。其课题组的主要研究方向为化学生物学、药物化学和有机方法学,以及它们在传染性疾病和表观遗传学相关领域的应用。

教育背景

2006.9 - 2011.7 药物化学专业,博士学位,中国科学院上海药物研究所

工作经历

2011.10 - 2014.3 博士后,骨科和物理康复科,麻省大学医学院(Department of Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School

2014.3 - 2018.01  博士后,佐治亚大学药学院(College of Pharmacy, University of Georgia

科研项目

1. 高水平大学建设杏林人才科研配套经费,2018/03-2021/03

2. 广东省科技厅, 广东省基础与应用基础研究基金联合基金青年基金项目, 2020/01-2022/12

3. 广东省教育厅, 广东省普通高校青年创新人才类项目, 2020/03-2022/03

代表性论文

After joining GZUCM

1. Chen, H.; Zhao, H.; Xiang, L.; Wu, H.; Liang, Y.; Huang, X. A. #; Zhang, J#. Aldol sensor-inspired fluorescent probes for measuring protein citrullination. Org. Biomol. Chem. 2020, 18, 5120-5124.

2. Xiang, L.; Wu, H.; Liang, Y.; Deng, H.; He, Y.; Xu, Q. #; Zhang, J#. Ag(i)-catalyzed rapid access to 2-amino-4-methylenethiazolines with potential applications in bioconjugation chemistry. Org. Biomol. Chem. 2021, 19, 4060-4066.

3. Xu, X. *; Zhang, J. *; Filion, T. M.; Akalin, A.; Song, J. Modulating mechanical and shape-memory properties while mitigating degradation-induced inflammation of polylactides by pendant aspirin incorporation. ACS Appl. Mater. Interfaces 2021, 13, 22271-22281. (* co-first author)

4. 陈汇鸿; 向玲玲; 梁韵诗; 伍海婷; 黄新安#; 张静#. 天花粉中瓜氨酸含量的荧光检测. 中南药学 2021, 19, 2043-2045.

5. He, Y.; Wu, H.; Liang, Y.; Deng, H.; Xiang, L.; Gu, J.; Zhang, J. Regioselective access to 2-iminoimidazolidines via agf-mediated cascade reactions. J. Org. Chem. 2022, 87, 7480-7486.

Before joining GZUCM

1. Melody D. Fulton*, Jing Zhang*, Maomao He, Meng-Chiao Ho, Yujun George Zheng. Intricate Effects of α-Amino and Lysine Modifications on Arginine Methylation of the N-Terminal Tail of Histone H4. Biochemistry. 2017, 56, 3539-3548. (* co-first author)

2. Jing Zhang*, Kun Qian*, Chunli Yan, Maomao He, Brenson A. Jassim, Ivaylo Ivanov, Yujun George Zheng. Discovery of decamidine as a new and potent PRMT1 inhibitor. Med. Chem. Commun., 2017, 8, 440-444. (* co-first author)

3. Jing Zhang, George Yujun Zheng. SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases. ACS Chem Biol. 2016, 11, 583-97.

4. Ruo-Jing Li, Jing Xu, Chenglai Fu, Jing Zhang, Yujun George Zheng, Hao Jia, Jun O Liu. Regulation of mTORC1 by lysosomal calcium and calmodulin. eLife. 2016, 5, e19360.

5. Yepeng Luan, Levi L. Blazer, Hao Hu, Taraneh Hajian, Jing Zhang, Hong Wu, Scott Houliston, Chery H. Arrowsmith, Masoud Vedadi, Yujun George Zheng. Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1. Org. Biomol. Chem. 2016, 14, 631-638.

6. Jing Zhang, Jiye Huang, Zilan Song, Lin Guo, Wenxian Cai, Yun Wang, Xuechu Zhen, Ao Zhang. Structural manipulation on the catecholic fragment of dopamine D1 receptor agonist 1-phenyl-N-methyl-benzazepines. Eur. J. Med. Chem. 2014, 85, 16-26.

7. Jing Zhang, Jie Song. Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. Acta Biomaterialia. 2014, 10, 3079-3090.

8. Zhiqing Liu, Jing Ai, Xia Peng, Zilan Song, Kui Wu, Jing Zhang, Qizheng Yao, Yi Chen, Yinchun Ji, Yanhong Yang, Mei-Yu Geng, Ao Zhang. Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities. ACS Med Chem Lett. 2014, 5, 304-308.

9. Jing Zhang, Kui Wu, Meining Wang, Jianqin Jiang and Ao Zhang. FeCl3·6H2O-Promoted Skeleton-Rearrangement of 1-Substituted-3-benzazepines: Substrate Extension and Product Utilization. Tetrahedron. 2011, 67, 842-848.

10. Zhili Liu, Hai Zhang, Na Ye, Jing Zhang, QianQian Wu, Peihua Sun, Linyong Li, Xuechu Zhen, and Ao Zhang. Synthesis of Dihydrofuroaporphine Derivatives: Identification of a Potent and Selective Serotonin 5-HT1A Receptor Agonist. J. Med. Chem. 2010, 53, 1319-1328.

11. Jing Zhang, Bing Xiong, Xuechu Zhen and Ao Zhang. Dopamine D1 receptor ligands: where are we now and where are we going. Med. Res. Rev. 2009, 29, 272-294.

12. Jing Zhang, Hai Zhang, Wenxian Cai, Leiping Yu, Xuechu Zhen and Ao Zhang. 'Click' D1 receptor agonists with a 5-HT1A receptor pharmacophore producing D2 receptor activity. Bioorg. Med. Chem. 2009, 17, 4873-4880.

13. Jing Zhang, Ao Zhang. Unprecedented FeCl3 6H2O-promoted skeleton rearrangement of 1-aryl-2,3,4,5-tetrahydro-1H-3-benzazepines: a new strategy for the synthesis of C1 quaternary tetrahydroisoquinolines. Chem. Eur. J. 2009, 15, 11119-11122.

14. Zhili Liu, Jing Zhang and Ao Zhang. Design of multivalent ligand targeting G-protein-coupled receptors. Curr. Pharm. Des. 2009, 15, 682-718.

15. Xueqing Chen, Jing Zhang, John L Neumeyer, Guozhang Jin, Guoyuan Hu, Ao Zhang and Xuechu Zhen. Arylbenzazepines are potent modulators for the delayed rectifier K+ channel: a potential mechanism for their neuroprotective effects. Plos One 2009, 4, e5811.

16. Jing Zhang, Xuetao Chen, Leiping Yu, Xuechu Zhen and Ao Zhang. Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D1 receptor activities. Bioorg. Med. Chem. 2008, 16, 9425-9431.


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